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IgD+ age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged.
Kugler-Umana O, Zhang W, Kuang Y, Liang J, Castonguay CH, Tonkonogy SL, Marshak-Rothstein A, Devarajan P, Swain SL. Kugler-Umana O, et al. Aging Cell. 2022 Oct;21(10):e13705. doi: 10.1111/acel.13705. Epub 2022 Sep 2. Aging Cell. 2022. PMID: 36056604 Free PMC article.
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