Mononuclear phagocyte morphologic response to chemoattractants is dependent on geranylgeranyl pyrophosphate.
Krauklis SA, Hussain J, Murphy KM, Dray EL, Ousley CG, Justyna K, Distefano MD, Steelman AJ, McKim DB.
Krauklis SA, et al.
Am J Physiol Endocrinol Metab. 2024 May 8. doi: 10.1152/ajpendo.00359.2023. Online ahead of print.
Am J Physiol Endocrinol Metab. 2024.
PMID: 38717364
The inhibitory effect of simvastatin treatment was unaffected by the addition of either farnesyl pyrophosphate (FPP) or squalene, but was reversed by restoring geranylgeranyl pyrophosphate (GGPP). Treatment with prenyltransferase inhibitors showed that the chemoattractant …
The inhibitory effect of simvastatin treatment was unaffected by the addition of either farnesyl pyrophosphate (FPP) or squalene, but was re …