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Page 1
Formation of amyloid fibers by monomeric light chain variable domains.
Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS. Brumshtein B, et al. J Biol Chem. 2014 Oct 3;289(40):27513-25. doi: 10.1074/jbc.M114.585638. Epub 2014 Aug 19. J Biol Chem. 2014. PMID: 25138218 Free PMC article.
Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS. Sawaya MR, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12769-74. doi: 10.1073/pnas.1413456111. Epub 2014 Aug 18. Proc Natl Acad Sci U S A. 2014. PMID: 25136092 Free PMC article.
The zipper groups of the amyloid state of proteins.
Stroud JC. Stroud JC. Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):540-5. doi: 10.1107/S0907444912050548. Epub 2013 Mar 9. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23519662 Free PMC article.
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. Liu C, et al. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20913-8. doi: 10.1073/pnas.1218792109. Epub 2012 Dec 3. Proc Natl Acad Sci U S A. 2012. PMID: 23213214 Free PMC article.
Toxic fibrillar oligomers of amyloid-β have cross-β structure.
Stroud JC, Liu C, Teng PK, Eisenberg D. Stroud JC, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7717-22. doi: 10.1073/pnas.1203193109. Epub 2012 Apr 30. Proc Natl Acad Sci U S A. 2012. PMID: 22547798 Free PMC article.