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Phase II study of irinotecan (CPT-11) administered every 2 weeks as treatment for patients with colorectal cancer resistant to previous treatment with 5-fluorouracil-based therapies: comparison of two different dose schedules (250 and 200 mg/m2) according to toxicity prognostic factors.
Saigi E, Salut A, Campos JM, Losa F, Manzano H, Batiste-Alentorn E, Acusa A, Vélez de Mendizabal E, Guasch I, Antón I; ACROSS Cooperative Group. Saigi E, et al. Anticancer Drugs. 2004 Oct;15(9):835-41. doi: 10.1097/00001813-200410000-00003. Anticancer Drugs. 2004. PMID: 15457123 Clinical Trial.
Cetuximab given every 2 weeks plus irinotecan is an active and safe option for previously treated patients with metastatic colorectal cancer.
Roca JM, Alonso V, Pericay C, Escudero P, Salud A, Losa F, López LJ, Guasch I, Méndez M, Quintero-Aldana G, Grande C, Vicente P, Arrivi A, Martin C, Moreno I, García P, Antón I, Constenla M, Yubero A, Cirera L; ACROSS Cooperative Group. Roca JM, et al. Chemotherapy. 2010;56(2):142-6. doi: 10.1159/000313527. Epub 2010 Apr 21. Chemotherapy. 2010. PMID: 20407241 Clinical Trial.