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Year Number of Results
2019 25
2020 28
2021 32
2022 24
2023 35
2024 27

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160 results

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Page 1
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Salas-Lloret D, García-Rodríguez N, Soto-Hidalgo E, González-Vinceiro L, Espejo-Serrano C, Giebel L, Mateos-Martín ML, de Ru AH, van Veelen PA, Huertas P, Vertegaal ACO, González-Prieto R. Salas-Lloret D, et al. Nat Commun. 2024 May 20;15(1):4292. doi: 10.1038/s41467-024-48427-6. Nat Commun. 2024. PMID: 38769345
BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer with ubiquitin E3 activity. The relevance of the BRCA1/BARD1 ubiquitin E3 activity for tumor suppression and DNA repair remains controversial. ...These …
BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer with ubiquitin E3 acti …
Cortico-cortical transfer of socially derived information gates emotion recognition.
Dautan D, Monai A, Maltese F, Chang X, Molent C, Mauro D, Galbusera A, Vecchia D, Antonelli F, Benedetti A, Drago F, Leggio GM, Pagani M, Fellin T, Gozzi A, Schumann G, Managò F, Papaleo F. Dautan D, et al. Nat Neurosci. 2024 May 20. doi: 10.1038/s41593-024-01647-x. Online ahead of print. Nat Neurosci. 2024. PMID: 38769153
Through optogenetic manipulations and Ca(2+) imaging fiber photometry in mice and functional imaging in humans, we demonstrate the specific participation of these long-range SOM projections from the mPFC to the RSC, and an excitatory feedback loop from the RSC to th …
Through optogenetic manipulations and Ca(2+) imaging fiber photometry in mice and functional imaging in humans, we demonstrate the …
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Khani S, et al. Nat Metab. 2024 Apr 29. doi: 10.1038/s42255-024-01033-8. Online ahead of print. Nat Metab. 2024. PMID: 38684889
Promoting brown adipose tissue (BAT) activity innovatively targets obesity and metabolic disease. While thermogenic activation of BAT is well understood, the rheostatic regulation of BAT to avoid excessive energy dissipation remains ill-defined. ...Thus, AC3-AT acts …
Promoting brown adipose tissue (BAT) activity innovatively targets obesity and metabolic disease. While thermogenic activation …
Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model.
Bataveljic D, Pivonkova H, de Concini V, Hébert B, Ezan P, Briault S, Bemelmans AP, Pichon J, Menuet A, Rouach N. Bataveljic D, et al. Nat Commun. 2024 Apr 27;15(1):3583. doi: 10.1038/s41467-024-47681-y. Nat Commun. 2024. PMID: 38678030 Free PMC article.
Finally, we show that the deficit in astroglial Kir4.1 underlies neuronal hyperexcitability and several behavioral defects in Fmr1 knockout mice. Viral delivery of Kir4.1 channels specifically to hippocampal astrocytes from Fmr1 knockout mice indeed rescues normal astrocyt …
Finally, we show that the deficit in astroglial Kir4.1 underlies neuronal hyperexcitability and several behavioral defects in Fmr1 knockout …
Autonomous quantum heat engine based on non-Markovian dynamics of an optomechanical Hamiltonian.
Rasola M, Möttönen M. Rasola M, et al. Sci Rep. 2024 Apr 24;14(1):9448. doi: 10.1038/s41598-024-59881-z. Sci Rep. 2024. PMID: 38658607 Free PMC article.
We propose a recipe for demonstrating an autonomous quantum heat engine where the working fluid consists of a harmonic oscillator, the frequency of which is tuned by a driving mode. ...This general theoretical proposal heralds the in-depth studies of quantum heat engines i …
We propose a recipe for demonstrating an autonomous quantum heat engine where the working fluid consists of a harmonic oscillator, th …
Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds.
Zhang BC, Laursen MF, Hu L, Hazrati H, Narita R, Jensen LS, Hansen AS, Huang J, Zhang Y, Ding X, Muyesier M, Nilsson E, Banasik A, Zeiler C, Mogensen TH, Etzerodt A, Agger R, Johannsen M, Kofod-Olsen E, Paludan SR, Jakobsen MR. Zhang BC, et al. Nat Commun. 2024 Mar 29;15(1):2760. doi: 10.1038/s41467-024-47046-5. Nat Commun. 2024. PMID: 38553448 Free PMC article.
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly and ind …
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microen …
Transient expression of the neuropeptide galanin modulates peripheral-to-central connectivity in the somatosensory thalamus during whisker development in mice.
Hevesi Z, Bakker J, Tretiakov EO, Adori C, Raabgrund A, Barde SS, Caramia M, Krausgruber T, Ladstätter S, Bock C, Hökfelt T, Harkany T. Hevesi Z, et al. Nat Commun. 2024 Mar 29;15(1):2762. doi: 10.1038/s41467-024-47054-5. Nat Commun. 2024. PMID: 38553447 Free PMC article.
The significance of transient neuropeptide expression during postnatal brain development is unknown. Here, we show that galanin expression in the ventrobasal thalamus of infant mice coincides with whisker map development and modulates subcortical circuit wiring. ... …
The significance of transient neuropeptide expression during postnatal brain development is unknown. Here, we show that galanin expre …
The brown seaweed Ectocarpus.
Coelho SM. Coelho SM. Nat Methods. 2024 Mar;21(3):363-364. doi: 10.1038/s41592-024-02198-6. Nat Methods. 2024. PMID: 38472460 No abstract available.
160 results