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Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.
Glaros V, Rauschmeier R, Artemov AV, Reinhardt A, Ols S, Emmanouilidi A, Gustafsson C, You Y, Mirabello C, Björklund ÅK, Perez L, King NP, Månsson R, Angeletti D, Loré K, Adameyko I, Busslinger M, Kreslavsky T. Glaros V, et al. Immunity. 2021 Sep 14;54(9):2005-2023.e10. doi: 10.1016/j.immuni.2021.08.017. Immunity. 2021. PMID: 34525339 Free PMC article.
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M. Calderón L, et al. Sci Immunol. 2021 Jul 23;6(61):eabg5003. doi: 10.1126/sciimmunol.abg5003. Sci Immunol. 2021. PMID: 34301800 Free PMC article.
Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.
Hill L, Ebert A, Jaritz M, Wutz G, Nagasaka K, Tagoh H, Kostanova-Poliakova D, Schindler K, Sun Q, Bönelt P, Fischer M, Peters JM, Busslinger M. Hill L, et al. Nature. 2020 Aug;584(7819):142-147. doi: 10.1038/s41586-020-2454-y. Epub 2020 Jul 1. Nature. 2020. PMID: 32612238 Free PMC article.