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TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.
Pasquier A, Pastore N, D'Orsi L, Colonna R, Esposito A, Maffia V, De Cegli R, Mutarelli M, Ambrosio S, Tufano G, Grimaldi A, Cesana M, Cacchiarelli D, Delalleau N, Napolitano G, Ballabio A. Pasquier A, et al. EMBO J. 2023 Nov 2;42(21):e113928. doi: 10.15252/embj.2023113928. Epub 2023 Sep 15. EMBO J. 2023. PMID: 37712288 Free PMC article.
Non-canonical mTORC1 signaling at the lysosome.
Napolitano G, Di Malta C, Ballabio A. Napolitano G, et al. Trends Cell Biol. 2022 Nov;32(11):920-931. doi: 10.1016/j.tcb.2022.04.012. Epub 2022 May 30. Trends Cell Biol. 2022. PMID: 35654731 Free article. Review.
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Napolitano G, Di Malta C, Esposito A, de Araujo MEG, Pece S, Bertalot G, Matarese M, Benedetti V, Zampelli A, Stasyk T, Siciliano D, Venuta A, Cesana M, Vilardo C, Nusco E, Monfregola J, Calcagnì A, Di Fiore PP, Huber LA, Ballabio A. Napolitano G, et al. Nature. 2020 Sep;585(7826):597-602. doi: 10.1038/s41586-020-2444-0. Epub 2020 Jul 1. Nature. 2020. PMID: 32612235 Free PMC article.
TFEB controls vascular development by regulating the proliferation of endothelial cells.
Doronzo G, Astanina E, Corà D, Chiabotto G, Comunanza V, Noghero A, Neri F, Puliafito A, Primo L, Spampanato C, Settembre C, Ballabio A, Camussi G, Oliviero S, Bussolino F. Doronzo G, et al. EMBO J. 2019 Feb 1;38(3):e98250. doi: 10.15252/embj.201798250. Epub 2018 Dec 27. EMBO J. 2019. PMID: 30591554 Free PMC article.