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754 results

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Aging clocks based on accumulating stochastic variation.
Meyer DH, Schumacher B. Meyer DH, et al. Nat Aging. 2024 May 9. doi: 10.1038/s43587-024-00619-x. Online ahead of print. Nat Aging. 2024. PMID: 38724736
The reproducibility of accurate aging clocks has reinvigorated the debate on whether a programmed process underlies aging. Here we show that accumulating stochastic variation in purely simulated data is sufficient to build aging clocks, and that first-generation and second …
The reproducibility of accurate aging clocks has reinvigorated the debate on whether a programmed process underlies aging. Here we sh …
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression.
Lozano-Vidal N, Stanicek L, Bink DI, Juni RP, Hooglugt A, Kremer V, Phelp P, van Bergen A, MacInnes AW, Dimmeler S, Boon RA. Lozano-Vidal N, et al. Commun Biol. 2024 May 7;7(1):541. doi: 10.1038/s42003-024-06230-5. Commun Biol. 2024. PMID: 38714838 Free PMC article.
Findings are validate in vivo using endothelial-specific inducible PNUTS-deficient mice (Cdh5-CreERT2;PNUTS(fl/fl)), termed PNUTS(EC-KO). Two weeks after PNUTS deletion, PNUTS(EC-KO) mice present severe multiorgan failure and vascular leakage. Transcriptomic analysi …
Findings are validate in vivo using endothelial-specific inducible PNUTS-deficient mice (Cdh5-CreERT2;PNUTS(fl/fl)), termed PNUTS(EC- …
The 1+Million Genomes Minimal Dataset for Cancer.
Riba M, Sala C, Culhane AC, Flobak Å, Patocs A, Boye K, Plevova K, Pospíšilová Š, Gandolfi G, Morelli MJ, Bucci G, Edsjö A, Lassen U, Al-Shahrour F, Lopez-Bigas N, Hovland R, Cuppen E, Valencia A, Poirel HA, Rosenquist R, Scollen S, Arenas Marquez J, Belien J, De Nicolo A, De Maria R, Torrents D, Tonon G. Riba M, et al. Nat Genet. 2024 May 3. doi: 10.1038/s41588-024-01721-x. Online ahead of print. Nat Genet. 2024. PMID: 38702538 No abstract available.
A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.
Saldana-Guerrero IM, Montano-Gutierrez LF, Boswell K, Hafemeister C, Poon E, Shaw LE, Stavish D, Lea RA, Wernig-Zorc S, Bozsaky E, Fetahu IS, Zoescher P, Pötschger U, Bernkopf M, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S, Shoeb MR, Bozatzi P, Rados M, Guarini M, Buri MC, Weninger W, Putz EM, Huang M, Ladenstein R, Andrews PW, Barbaric I, Cresswell GD, Bryant HE, Distel M, Chesler L, Taschner-Mandl S, Farlik M, Tsakiridis A, Halbritter F. Saldana-Guerrero IM, et al. Nat Commun. 2024 May 3;15(1):3745. doi: 10.1038/s41467-024-47945-7. Nat Commun. 2024. PMID: 38702304 Free PMC article.
These changes correlate with a stepwise aberration of developmental transcription factor networks. Together, our results sketch a mechanistic framework for the CNA-driven initiation of embryonal tumours....
These changes correlate with a stepwise aberration of developmental transcription factor networks. Together, our results sketch a mechanisti …
754 results