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A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets.
Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O'Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW. Li X, et al. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2110557119. doi: 10.1073/pnas.2110557119. Epub 2022 Apr 20. Proc Natl Acad Sci U S A. 2022. PMID: 35442775 Free PMC article.
Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers.
Montinaro A, Areso Zubiaur I, Saggau J, Kretz AL, Ferreira RMM, Hassan O, Kitzig E, Müller I, El-Bahrawy MA, von Karstedt S, Kulms D, Liccardi G, Lemke J, Walczak H. Montinaro A, et al. Cell Death Differ. 2022 Mar;29(3):492-503. doi: 10.1038/s41418-021-00869-x. Epub 2021 Sep 17. Cell Death Differ. 2022. PMID: 34535764 Free PMC article.
Dual roles for LUBAC signaling in thymic epithelial cell development and survival.
Jain R, Zhao K, Sheridan JM, Heinlein M, Kupresanin F, Abeysekera W, Hall C, Rickard J, Bouillet P, Walczak H, Strasser A, Silke J, Gray DHD. Jain R, et al. Cell Death Differ. 2021 Oct;28(10):2946-2956. doi: 10.1038/s41418-021-00850-8. Epub 2021 Aug 11. Cell Death Differ. 2021. PMID: 34381167 Free PMC article.