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2016 1
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Page 1
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells.
Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Urya H, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MA. Zhang L, et al. bioRxiv [Preprint]. 2024 Jan 17:2023.08.31.555634. doi: 10.1101/2023.08.31.555634. bioRxiv. 2024. PMID: 37693622 Free PMC article. Preprint.
Multiparameter prediction of myeloid neoplasia risk.
Gu M, Kovilakam SC, Dunn WG, Marando L, Barcena C, Mohorianu I, Smith A, Kar SP, Fabre MA, Gerstung M, Cargo CA, Malcovati L, Quiros PM, Vassiliou GS. Gu M, et al. Nat Genet. 2023 Sep;55(9):1523-1530. doi: 10.1038/s41588-023-01472-1. Epub 2023 Aug 24. Nat Genet. 2023. PMID: 37620601 Free PMC article.
Genetic Predisposition to Clonal Hematopoiesis.
Quiros PM, Vassiliou GS. Quiros PM, et al. Hemasphere. 2023 Aug 17;7(9):e947. doi: 10.1097/HS9.0000000000000947. eCollection 2023 Sep. Hemasphere. 2023. PMID: 37600859 Free PMC article. No abstract available.
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages.
Sturgess K, Yankova E, Vijayabaskar MS, Isobe T, Rak J, Kucinski I, Barile M, Webster NA, Eleftheriou M, Hannah R, Gozdecka M, Vassiliou G, Rausch O, Wilson NK, Göttgens B, Tzelepis K. Sturgess K, et al. Leukemia. 2023 Oct;37(10):2133-2137. doi: 10.1038/s41375-023-01965-2. Epub 2023 Jul 19. Leukemia. 2023. PMID: 37464070 Free PMC article. No abstract available.
Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients.
Stelmach P, Richter S, Sauer S, Fabre MA, Gu M, Rohde C, Janssen M, Liebers N, Proynova R, Weinhold N, Raab MS, Goldschmidt H, Besenbeck B, Pavel P, Laier S, Trumpp A, Dietrich S, Vassiliou GS, Müller-Tidow C. Stelmach P, et al. Haematologica. 2023 Dec 1;108(12):3308-3320. doi: 10.3324/haematol.2023.282992. Haematologica. 2023. PMID: 37381752 Free PMC article.
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.
Wang M, Brandt LTL, Wang X, Russell H, Mitchell E, Kamimae-Lanning AN, Brown JM, Dingler FA, Garaycoechea JI, Isobe T, Kinston SJ, Gu M, Vassiliou GS, Wilson NK, Göttgens B, Patel KJ. Wang M, et al. Mol Cell. 2023 Jul 20;83(14):2417-2433.e7. doi: 10.1016/j.molcel.2023.05.035. Epub 2023 Jun 21. Mol Cell. 2023. PMID: 37348497 Free PMC article.
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS, Asby R, van de Lagemaat LN, Mapperley C, James SC, Prehn JHM, Tzelepis K, Rouault-Pierre K, Vassiliou GS, Kranc KR, Helgason GV, Huntly BJP, Gallipoli P. Woodley K, et al. Nat Commun. 2023 Apr 14;14(1):2132. doi: 10.1038/s41467-023-37652-0. Nat Commun. 2023. PMID: 37059720 Free PMC article.
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Fischer A, Lersch R, de Andrade Krätzig N, Strong A, Friedrich MJ, Weber J, Engleitner T, Öllinger R, Yen HY, Kohlhofer U, Gonzalez-Menendez I, Sailer D, Kogan L, Lahnalampi M, Laukkanen S, Kaltenbacher T, Klement C, Rezaei M, Ammon T, Montero JJ, Schneider G, Mayerle J, Heikenwälder M, Schmidt-Supprian M, Quintanilla-Martinez L, Steiger K, Liu P, Cadiñanos J, Vassiliou GS, Saur D, Lohi O, Heinäniemi M, Conte N, Bradley A, Rad L, Rad R. Fischer A, et al. Cell Genom. 2023 Mar 8;3(3):100276. doi: 10.1016/j.xgen.2023.100276. eCollection 2023 Mar 8. Cell Genom. 2023. PMID: 36950387 Free PMC article.
70 results