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Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.
Mohseni YR, Saleem A, Tung SL, Dudreuilh C, Lang C, Peng Q, Volpe A, Adigbli G, Cross A, Hester J, Farzaneh F, Scotta C, Lechler RI, Issa F, Fruhwirth GO, Lombardi G. Mohseni YR, et al. Eur J Immunol. 2021 Oct;51(10):2522-2530. doi: 10.1002/eji.202048934. Epub 2021 Aug 8. Eur J Immunol. 2021. PMID: 34320225 Free PMC article.
Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment.
Jacob J, Nadkarni S, Volpe A, Peng Q, Tung SL, Hannen RF, Mohseni YR, Scotta C, Marelli-Berg FM, Lechler RI, Smyth LA, Fruhwirth GO, Lombardi G. Jacob J, et al. Mol Ther Methods Clin Dev. 2020 Dec 10;20:324-336. doi: 10.1016/j.omtm.2020.12.003. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33511246 Free PMC article.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL, Karagiannis SN, Penin RM, Marcolval J, Marti RM, Matias-Guiu X, Fruhwirth GO, Orgaz JL, Malanchi I, Sanz-Moreno V. Rodriguez-Hernandez I, et al. Nat Commun. 2020 Oct 20;11(1):5315. doi: 10.1038/s41467-020-18951-2. Nat Commun. 2020. PMID: 33082334 Free PMC article.
29 results