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Year Number of Results
2018 1
2019 1
2020 3
2021 7
2023 2
2024 0

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13 results

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Page 1
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages.
Sturgess K, Yankova E, Vijayabaskar MS, Isobe T, Rak J, Kucinski I, Barile M, Webster NA, Eleftheriou M, Hannah R, Gozdecka M, Vassiliou G, Rausch O, Wilson NK, Göttgens B, Tzelepis K. Sturgess K, et al. Leukemia. 2023 Oct;37(10):2133-2137. doi: 10.1038/s41375-023-01965-2. Epub 2023 Jul 19. Leukemia. 2023. PMID: 37464070 Free PMC article. No abstract available.
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS, Asby R, van de Lagemaat LN, Mapperley C, James SC, Prehn JHM, Tzelepis K, Rouault-Pierre K, Vassiliou GS, Kranc KR, Helgason GV, Huntly BJP, Gallipoli P. Woodley K, et al. Nat Commun. 2023 Apr 14;14(1):2132. doi: 10.1038/s41467-023-37652-0. Nat Commun. 2023. PMID: 37059720 Free PMC article.
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. Orellana EA, et al. Mol Cell. 2021 Aug 19;81(16):3323-3338.e14. doi: 10.1016/j.molcel.2021.06.031. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352207 Free PMC article.
Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies.
Han N, Hwang W, Tzelepis K, Schmerer P, Yankova E, MacMahon M, Lei W, M Katritsis N, Liu A, Felgenhauer U, Schuldt A, Harris R, Chapman K, McCaughan F, Weber F, Kouzarides T. Han N, et al. Sci Adv. 2021 Jun 30;7(27):eabh3032. doi: 10.1126/sciadv.abh3032. Print 2021 Jun. Sci Adv. 2021. PMID: 34193418 Free PMC article.
SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML.
Pacharne S, Dovey OM, Cooper JL, Gu M, Friedrich MJ, Rajan SS, Barenboim M, Collord G, Vijayabaskar MS, Ponstingl H, De Braekeleer E, Bautista R, Mazan M, Rad R, Tzelepis K, Wright P, Gozdecka M, Vassiliou GS. Pacharne S, et al. Blood Adv. 2021 May 11;5(9):2412-2425. doi: 10.1182/bloodadvances.2020003443. Blood Adv. 2021. PMID: 33956058 Free PMC article.
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T. Yankova E, et al. Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26. Nature. 2021. PMID: 33902106 Free PMC article.
13 results