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Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA. Mukadam AS, et al. Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30. Science. 2023. PMID: 36996217 Free PMC article.
Target-induced clustering activates Trim-Away of pathogens and proteins.
Zeng J, Santos AF, Mukadam AS, Osswald M, Jacques DA, Dickson CF, McLaughlin SH, Johnson CM, Kiss L, Luptak J, Renner N, Vaysburd M, McEwan WA, Morais-de-Sá E, Clift D, James LC. Zeng J, et al. Nat Struct Mol Biol. 2021 Mar;28(3):278-289. doi: 10.1038/s41594-021-00560-2. Epub 2021 Feb 25. Nat Struct Mol Biol. 2021. PMID: 33633400 Free PMC article.