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Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE, Andrei SA, Ansell TB, Carrique L, Kumar P, Sefer L, Schwab RA, Byrne EFX, Pardon E, Steyaert J, Magee AI, Lanyon-Hogg T, Sansom MSP, Tate EW, Siebold C. Coupland CE, et al. Mol Cell. 2021 Dec 16;81(24):5025-5038.e10. doi: 10.1016/j.molcel.2021.11.018. Epub 2021 Dec 9. Mol Cell. 2021. PMID: 34890564 Free PMC article.
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.
Kallemeijn WW, Lanyon-Hogg T, Panyain N, Goya Grocin A, Ciepla P, Morales-Sanfrutos J, Tate EW. Kallemeijn WW, et al. Nat Protoc. 2021 Nov;16(11):5083-5122. doi: 10.1038/s41596-021-00601-6. Epub 2021 Oct 27. Nat Protoc. 2021. PMID: 34707257 Review.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547. doi: 10.1002/anie.202014457. Epub 2021 May 14. Angew Chem Int Ed Engl. 2021. PMID: 33768725 Free PMC article.
Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.
Alzahofi N, Welz T, Robinson CL, Page EL, Briggs DA, Stainthorp AK, Reekes J, Elbe DA, Straub F, Kallemeijn WW, Tate EW, Goff PS, Sviderskaya EV, Cantero M, Montoliu L, Nedelec F, Miles AK, Bailly M, Kerkhoff E, Hume AN. Alzahofi N, et al. Nat Commun. 2020 Jul 13;11(1):3495. doi: 10.1038/s41467-020-17212-6. Nat Commun. 2020. PMID: 32661310 Free PMC article.
23 results