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High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase.

Cerritelli SM, Iranzo J, Sharma S, Chabes A, Crouch RJ, Tollervey D, El Hage A. Cerritelli SM, et al. Nucleic Acids Res. 2020 May 7;48(8):4274-4297. doi: 10.1093/nar/gkaa103. Nucleic Acids Res. 2020. PMID: 32187369 Free PMC article.

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Regulation of the RNAPII Pool Is Integral to the DNA Damage Response.

Tufegdžić Vidaković A, Mitter R, Kelly GP, Neumann M, Harreman M, Rodríguez-Martínez M, Herlihy A, Weems JC, Boeing S, Encheva V, Gaul L, Milligan L, Tollervey D, Conaway RC, Conaway JW, Snijders AP, Stewart A, Svejstrup JQ. Tufegdžić Vidaković A, et al. Cell. 2020 Mar 19;180(6):1245-1261.e21. doi: 10.1016/j.cell.2020.02.009. Epub 2020 Mar 5. Cell. 2020. PMID: 32142654 Free PMC article.

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