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SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.
Dardaei L, Wang HQ, Singh M, Fordjour P, Shaw KX, Yoda S, Kerr G, Yu K, Liang J, Cao Y, Chen Y, Lawrence MS, Langenbucher A, Gainor JF, Friboulet L, Dagogo-Jack I, Myers DT, Labrot E, Ruddy D, Parks M, Lee D, DiCecca RH, Moody S, Hao H, Mohseni M, LaMarche M, Williams J, Hoffmaster K, Caponigro G, Shaw AT, Hata AN, Benes CH, Li F, Engelman JA. Dardaei L, et al. Nat Med. 2018 May;24(4):512-517. doi: 10.1038/nm.4497. Epub 2018 Mar 5. Nat Med. 2018. PMID: 29505033 Free PMC article.
Targeting the RB-E2F pathway in breast cancer.
Johnson J, Thijssen B, McDermott U, Garnett M, Wessels LF, Bernards R. Johnson J, et al. Oncogene. 2016 Sep 15;35(37):4829-35. doi: 10.1038/onc.2016.32. Epub 2016 Feb 29. Oncogene. 2016. PMID: 26923330 Free PMC article. Review.
Pharmacogenomic agreement between two cancer cell line data sets.
Cancer Cell Line Encyclopedia Consortium; Genomics of Drug Sensitivity in Cancer Consortium. Cancer Cell Line Encyclopedia Consortium, et al. Nature. 2015 Dec 3;528(7580):84-7. doi: 10.1038/nature15736. Epub 2015 Nov 16. Nature. 2015. PMID: 26570998 Free PMC article.