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Computer Optimization of Biodegradable Nanoparticles Fabricated by Dispersion Polymerization.
Int J Environ Res Public Health. 2015 Dec 22;13(1):ijerph13010047. doi: 10.3390/ijerph13010047.
Int J Environ Res Public Health. 2015.
PMID: 26703678
Free PMC article.
Solutions were returned from simultaneous optimization of the response variables for component combinations to (1) minimize nanoparticle size; (2) maximize the surface negative zeta potential; and (3) maximize percent yield to make the nanoparticle fabrication an economic …
Solutions were returned from simultaneous optimization of the response variables for component combinations to (1) minimize nanoparti …
Polylactide-based paclitaxel-loaded nanoparticles fabricated by dispersion polymerization: characterization, evaluation in cancer cell lines, and preliminary biodistribution studies.
Adesina SK, Holly A, Kramer-Marek G, Capala J, Akala EO.
Adesina SK, et al.
J Pharm Sci. 2014 Aug;103(8):2546-55. doi: 10.1002/jps.24061. Epub 2014 Jun 24.
J Pharm Sci. 2014.
PMID: 24961596
Free PMC article.
Confocal microscopy reveals that the nanoparticles are internalized by MCF-7 breast cancer cells within 1 h. Preliminary biodistribution studies also show nanoparticle accumulation in tumor xenograft model. ...
Confocal microscopy reveals that the nanoparticles are internalized by MCF-7 breast cancer cells within 1 h. Preliminary biodistribut …
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Optimization of the fabrication of novel stealth PLA-based nanoparticles by dispersion polymerization using D-optimal mixture design.
Adesina SK, Wight SA, Akala EO.
Adesina SK, et al.
Drug Dev Ind Pharm. 2014 Nov;40(11):1547-56. doi: 10.3109/03639045.2013.838578. Epub 2013 Sep 23.
Drug Dev Ind Pharm. 2014.
PMID: 24059281
Free PMC article.
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Disposition of naltrexone after intravenous bolus administration in Wistar rats, low-alcohol-drinking rats and high-alcohol-drinking rats.
Akala EO, Wang H, Adedoyin A.
Akala EO, et al.
Neuropsychobiology. 2008;58(2):81-90. doi: 10.1159/000159776. Epub 2008 Oct 3.
Neuropsychobiology. 2008.
PMID: 18832863
Free PMC article.
Results show a high clearance that is close to or higher than hepatic blood flow in all groups (Wistar > LAD-1 > HAD-1, but with a statistically significant difference only between Wistar and HAD-1). Volume of distribution (approximately 2.5-3 l/kg) and …
Results show a high clearance that is close to or higher than hepatic blood flow in all groups (Wistar > LAD-1 > HAD-1, …
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