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Page 1
Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization.
Lapuente D, Fuchs J, Willar J, Vieira Antão A, Eberlein V, Uhlig N, Issmail L, Schmidt A, Oltmanns F, Peter AS, Mueller-Schmucker S, Irrgang P, Fraedrich K, Cara A, Hoffmann M, Pöhlmann S, Ensser A, Pertl C, Willert T, Thirion C, Grunwald T, Überla K, Tenbusch M. Lapuente D, et al. Nat Commun. 2021 Nov 26;12(1):6871. doi: 10.1038/s41467-021-27063-4. Nat Commun. 2021. PMID: 34836955 Free PMC article.
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency.
Arora P, Rocha C, Kempf A, Nehlmeier I, Graichen L, Winkler MS, Lier M, Schulz S, Jäck HM, Cossmann A, Stankov MV, Behrens GMN, Pöhlmann S, Hoffmann M. Arora P, et al. Cell Mol Immunol. 2021 Dec;18(12):2673-2675. doi: 10.1038/s41423-021-00779-5. Epub 2021 Oct 25. Cell Mol Immunol. 2021. PMID: 34697413 Free PMC article. No abstract available.
Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance.
Arora P, Kempf A, Nehlmeier I, Graichen L, Sidarovich A, Winkler MS, Schulz S, Jäck HM, Stankov MV, Behrens GMN, Pöhlmann S, Hoffmann M. Arora P, et al. Cell Mol Immunol. 2021 Nov;18(11):2557-2559. doi: 10.1038/s41423-021-00772-y. Epub 2021 Oct 11. Cell Mol Immunol. 2021. PMID: 34635807 Free PMC article. No abstract available.
Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination.
Hammerschmidt SI, Bosnjak B, Bernhardt G, Friedrichsen M, Ravens I, Dopfer-Jablonka A, Hoffmann M, Pöhlmann S, Behrens GMN, Förster R. Hammerschmidt SI, et al. Cell Mol Immunol. 2021 Oct;18(10):2455-2456. doi: 10.1038/s41423-021-00755-z. Epub 2021 Aug 23. Cell Mol Immunol. 2021. PMID: 34426672 Free PMC article. No abstract available.
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination.
Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Förster R, Behrens GMN. Barros-Martins J, et al. Nat Med. 2021 Sep;27(9):1525-1529. doi: 10.1038/s41591-021-01449-9. Epub 2021 Jul 14. Nat Med. 2021. PMID: 34262158 Free PMC article.
LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.
Ludwig KU, Schmithausen RM, Li D, Jacobs ML, Hollstein R, Blumenstock K, Liebing J, Słabicki M, Ben-Shmuel A, Israeli O, Weiss S, Ebert TS, Paran N, Rüdiger W, Wilbring G, Feldman D, Lippke B, Ishorst N, Hochfeld LM, Beins EC, Kaltheuner IH, Schmitz M, Wöhler A, Döhla M, Sib E, Jentzsch M, Moench EC, Borrajo JD, Strecker J, Reinhardt J, Cleary B, Geyer M, Hölzel M, Macrae R, Nöthen MM, Hoffmann P, Exner M, Regev A, Zhang F, Schmid-Burgk JL. Ludwig KU, et al. Nat Biotechnol. 2021 Dec;39(12):1556-1562. doi: 10.1038/s41587-021-00966-9. Epub 2021 Jun 29. Nat Biotechnol. 2021. PMID: 34188222 Free PMC article.
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
Trump S, Lukassen S, Anker MS, Chua RL, Liebig J, Thürmann L, Corman VM, Binder M, Loske J, Klasa C, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Völker MT, Müller SD, Liebert UG, Ishaque N, Kaderali L, Sander LE, Drosten C, Laudi S, Eils R, Conrad C, Landmesser U, Lehmann I. Trump S, et al. Nat Biotechnol. 2021 Jun;39(6):705-716. doi: 10.1038/s41587-020-00796-1. Epub 2020 Dec 24. Nat Biotechnol. 2021. PMID: 33361824