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A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Peters DE, Norris LD, Tenora L, Šnajdr I, Ponti AK, Zhu X, Sakamoto S, Veeravalli V, Pradhan M, Alt J, Thomas AG, Majer P, Rais R, McDonald C, Slusher BS. Peters DE, et al. Among authors: snajdr i. Sci Transl Med. 2023 Aug 9;15(708):eabn7491. doi: 10.1126/scitranslmed.abn7491. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556558 Free PMC article.
Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction.
Tumova S, Milacek M, Šnajdr I, Muthu M, Tuma R, Reha D, Jedlicka P, Bittova L, Novotna A, Majer P, Sedlak D, Jindra M. Tumova S, et al. Among authors: snajdr i. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2215541119. doi: 10.1073/pnas.2215541119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409882 Free PMC article.
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.
Tsai J, Gori S, Alt J, Tiwari S, Iyer J, Talwar R, Hinsu D, Ahirwar K, Mohanty S, Khunt C, Sutariya B, Jani K, Venkatasubbaiah V, Patel A, Meghapara J, Joshi K, Sahu R, Rana V, Nigade P, Talluri RS, Murty KVSN, Joshi K, Ramanathan V, Li A, Islam N, Snajdr I, Majer P, Rais R, Slusher BS, Garza LA. Tsai J, et al. Among authors: snajdr i. PNAS Nexus. 2022 Dec 16;2(1):pgac297. doi: 10.1093/pnasnexus/pgac297. eCollection 2023 Jan. PNAS Nexus. 2022. PMID: 36712931 Free PMC article.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Novotná K, Tenora L, Prchalová E, Paule J, Alt J, Veeravalli V, Lam J, Wu Y, Šnajdr I, Gori S, Mettu VS, Tsukamoto T, Majer P, Slusher BS, Rais R. Novotná K, et al. Among authors: snajdr i. J Med Chem. 2023 Nov 23;66(22):15493-15510. doi: 10.1021/acs.jmedchem.3c01681. Epub 2023 Nov 10. J Med Chem. 2023. PMID: 37949450 Free PMC article.
Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6).
Motlová L, Šnajdr I, Kutil Z, Andris E, Ptáček J, Novotná A, Nováková Z, Havlínová B, Tueckmantel W, Dráberová H, Majer P, Schutkowski M, Kozikowski A, Rulíšek L, Bařinka C. Motlová L, et al. Among authors: snajdr i. ACS Chem Biol. 2023 Jul 21;18(7):1594-1610. doi: 10.1021/acschembio.3c00212. Epub 2023 Jul 1. ACS Chem Biol. 2023. PMID: 37392419 Free PMC article.
Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.
Jedlickova L, Peterkova K, Boateng EM, Ulrychova L, Vacek V, Kutil Z, Jiang Z, Novakova Z, Snajdr I, Kim J, O'Donoghue AJ, Barinka C, Dvorak J. Jedlickova L, et al. Among authors: snajdr i. Parasit Vectors. 2022 Dec 20;15(1):480. doi: 10.1186/s13071-022-05556-5. Parasit Vectors. 2022. PMID: 36539882 Free PMC article.
12 results