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Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Skácel J, Djukic S, Baszczyňski O, Kalčic F, Bílek T, Chalupský K, Kozák J, Dvořáková A, Tloušt'ová E, Král'ová Z, Šmídková M, Voldřich J, Rumlová M, Pachl P, Brynda J, Vučková T, Fábry M, Snášel J, Pichová I, Řezáčová P, Mertlíková-Kaiserová H, Janeba Z. Skácel J, et al. Among authors: smidkova m. J Med Chem. 2023 May 25;66(10):6652-6681. doi: 10.1021/acs.jmedchem.2c02097. Epub 2023 May 3. J Med Chem. 2023. PMID: 37134237 Free PMC article.
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
Česnek M, Skácel J, Jansa P, Dračínský M, Šmídková M, Mertlíková-Kaiserová H, Soto-Velasquez MP, Watts VJ, Janeba Z. Česnek M, et al. Among authors: smidkova m. ChemMedChem. 2018 Sep 6;13(17):1779-1796. doi: 10.1002/cmdc.201800332. Epub 2018 Jul 31. ChemMedChem. 2018. PMID: 29968968 Free PMC article.
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Česnek M, Jansa P, Šmídková M, Mertlíková-Kaiserová H, Dračínský M, Brust TF, Pávek P, Trejtnar F, Watts VJ, Janeba Z. Česnek M, et al. Among authors: smidkova m. ChemMedChem. 2015 Aug;10(8):1351-64. doi: 10.1002/cmdc.201500183. Epub 2015 Jul 1. ChemMedChem. 2015. PMID: 26136378
Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?
Procházková E, Hřebabecký H, Dejmek M, Šála M, Šmídková M, Tloušťová E, Zborníková E, Eyer L, Růžek D, Nencka R. Procházková E, et al. Among authors: smidkova m. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126897. doi: 10.1016/j.bmcl.2019.126897. Epub 2019 Dec 17. Bioorg Med Chem Lett. 2020. PMID: 31882298
14 results