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Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole.
Juhás M, Bachtíková A, Nawrot DE, Hatoková P, Pallabothula VSK, Diepoltová A, Janďourek O, Bárta P, Konečná K, Paterová P, Šesták V, Zitko J. Juhás M, et al. Among authors: sestak v. Pharmaceuticals (Basel). 2022 May 6;15(5):580. doi: 10.3390/ph15050580. Pharmaceuticals (Basel). 2022. PMID: 35631406 Free PMC article.
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs.
Bures J, Tacheci I, Kvetina J, Radochova V, Prchal L, Kohoutova D, Valis M, Novak M, Dolezal R, Kopacova M, Rejchrt S, Sestak V, Knoblochova V, Peterova E, Zdarova Karasova J. Bures J, et al. Among authors: sestak v. Molecules. 2021 Apr 9;26(8):2160. doi: 10.3390/molecules26082160. Molecules. 2021. PMID: 33918638 Free PMC article.
The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs.
Bures J, Kvetina J, Radochova V, Tacheci I, Peterova E, Herman D, Dolezal R, Kopacova M, Rejchrt S, Douda T, Sestak V, Douda L, Karasova JZ. Bures J, et al. Among authors: sestak v. PLoS One. 2020 Jan 24;15(1):e0227781. doi: 10.1371/journal.pone.0227781. eCollection 2020. PLoS One. 2020. PMID: 31978146 Free PMC article.
1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats.
Zdarova Karasova J, Sestak V, Korabecny J, Mezeiova E, Palicka V, Kuca K, Mzik M. Zdarova Karasova J, et al. Among authors: sestak v. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:350-358. doi: 10.1016/j.jchromb.2018.06.034. Epub 2018 Jun 18. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29936371 No abstract available.
Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.
Sestak V, Stariat J, Cermanova J, Potuckova E, Chladek J, Roh J, Bures J, Jansova H, Prusa P, Sterba M, Micuda S, Simunek T, Kalinowski DS, Richardson DR, Kovarikova P. Sestak V, et al. Oncotarget. 2015 Dec 15;6(40):42411-28. doi: 10.18632/oncotarget.6389. Oncotarget. 2015. PMID: 26623727 Free PMC article.
Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats.
Stariat J, Suprunová V, Roh J, Šesták V, Eisner T, Filipský T, Mladěnka P, Nobilis M, Šimůnek T, Klimeš J, Kalinowski DS, Richardson DR, Kovaříková P. Stariat J, et al. Among authors: sestak v. Biomed Chromatogr. 2014 May;28(5):621-9. doi: 10.1002/bmc.3080. Epub 2013 Nov 20. Biomed Chromatogr. 2014. PMID: 24254882
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