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The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Kari V, Raul SK, Henck JM, Kitz J, Kramer F, Kosinsky RL, Übelmesser N, Mansour WY, Eggert J, Spitzner M, Najafova Z, Bastians H, Grade M, Gaedcke J, Wegwitz F, Johnsen SA. Kari V, et al. Among authors: ubelmesser n. Clin Epigenetics. 2019 Jan 7;11(1):4. doi: 10.1186/s13148-018-0601-1. Clin Epigenetics. 2019. PMID: 30616689 Free PMC article.
HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence.
Sofiadis K, Josipovic N, Nikolic M, Kargapolova Y, Übelmesser N, Varamogianni-Mamatsi V, Zirkel A, Papadionysiou I, Loughran G, Keane J, Michel A, Gusmao EG, Becker C, Altmüller J, Georgomanolis T, Mizi A, Papantonis A. Sofiadis K, et al. Among authors: ubelmesser n. Mol Syst Biol. 2021 Jun;17(6):e9760. doi: 10.15252/msb.20209760. Mol Syst Biol. 2021. PMID: 34166567 Free PMC article.
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
Zhang S, Übelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmüller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D, Papantonis A. Zhang S, et al. Among authors: ubelmesser n. Sci Adv. 2021 Oct 22;7(43):eabg8205. doi: 10.1126/sciadv.abg8205. Epub 2021 Oct 22. Sci Adv. 2021. PMID: 34678064 Free PMC article.