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Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease.
Darci-Maher N, Alvarez M, Arasu UT, Selvarajan I, Lee SHT, Pan DZ, Miao Z, Das SS, Kaminska D, Örd T, Benhammou JN, Wabitsch M, Pisegna JR, Männistö V, Pietiläinen KH, Laakso M, Sinsheimer JS, Kaikkonen MU, Pihlajamäki J, Pajukanta P. Darci-Maher N, et al. Among authors: ord t. EBioMedicine. 2023 Jun;92:104620. doi: 10.1016/j.ebiom.2023.104620. Epub 2023 May 22. EBioMedicine. 2023. PMID: 37224770 Free PMC article.
Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes.
Aherrahrou R, Lue D, Perry RN, Aberra YT, Khan MD, Soh JY, Örd T, Singha P, Yang Q, Gilani H, Benavente ED, Wong D, Hinkle J, Ma L, Sheynkman GM, den Ruijter HM, Miller CL, Björkegren JLM, Kaikkonen MU, Civelek M. Aherrahrou R, et al. Among authors: ord t. Circ Res. 2023 Feb 3;132(3):323-338. doi: 10.1161/CIRCRESAHA.122.321586. Epub 2023 Jan 4. Circ Res. 2023. PMID: 36597873 Free PMC article.
Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures.
Örd T, Lönnberg T, Nurminen V, Ravindran A, Niskanen H, Kiema M, Õunap K, Maria M, Moreau PR, Mishra PP, Palani S, Virta J, Liljenbäck H, Aavik E, Roivainen A, Ylä-Herttuala S, Laakkonen JP, Lehtimäki T, Kaikkonen MU. Örd T, et al. Am J Hum Genet. 2023 May 4;110(5):722-740. doi: 10.1016/j.ajhg.2023.03.013. Epub 2023 Apr 14. Am J Hum Genet. 2023. PMID: 37060905 Free PMC article.
ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component.
Jauhiainen S, Ilmonen H, Vuola P, Rasinkangas H, Pulkkinen HH, Keränen S, Kiema M, Liikkanen JJ, Laham-Karam N, Laidinen S, Beter M, Aavik E, Lappalainen K, Lohi J, Aronniemi J, Örd T, Kaikkonen MU, Salminen P, Tukiainen E, Ylä-Herttuala S, Laakkonen JP. Jauhiainen S, et al. Among authors: ord t. Elife. 2023 May 18;12:e82543. doi: 10.7554/eLife.82543. Elife. 2023. PMID: 37199488 Free PMC article.
The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium.
Anisimov A, Fang S, Hemanthakumar KA, Örd T, van Avondt K, Chevre R, Toropainen A, Singha P, Gilani H, Nguyen SD, Karaman S, Korhonen EA, Adams RH, Augustin HG, Öörni K, Soehnlein O, Kaikkonen MU, Alitalo K. Anisimov A, et al. Among authors: ord t. Nat Cardiovasc Res. 2023 Mar 13;2(3):307-321. doi: 10.1038/s44161-023-00224-y. Nat Cardiovasc Res. 2023. PMID: 37476204 Free PMC article.
Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations.
Aherrahrou R, Baig F, Theofilatos K, Lue D, Beele A, Örd T, Kaikkonen MU, Aherrahrou Z, Cheng Q, Ghosh S, Karnewar S, Karnewar V, Finn A, Owens GK, Joner M, Mayr M, Civelek M. Aherrahrou R, et al. Among authors: ord t. medRxiv [Preprint]. 2023 Nov 10:2023.11.10.23298351. doi: 10.1101/2023.11.10.23298351. medRxiv. 2023. PMID: 37986932 Free PMC article. Updated. Preprint.
Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.
Ravindran A, Holappa L, Niskanen H, Skovorodkin I, Kaisto S, Beter M, Kiema M, Selvarajan I, Nurminen V, Aavik E, Aherrahrou R, Pasonen-Seppänen S, Fortino V, Laakkonen JP, Ylä-Herttuala S, Vainio S, Örd T, Kaikkonen MU. Ravindran A, et al. Among authors: ord t. Cardiovasc Res. 2024 Jan 30:cvae028. doi: 10.1093/cvr/cvae028. Online ahead of print. Cardiovasc Res. 2024. PMID: 38289873
Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations.
Aherrahrou R, Baig F, Theofilatos K, Lue D, Beele A, Örd T, Kaikkonen MU, Aherrahrou Z, Cheng Q, Ghosh SKB, Karnewar S, Karnewar V, Finn AV, Owens GK, Joner M, Mayr M, Civelek M. Aherrahrou R, et al. Among authors: ord t. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):898-914. doi: 10.1161/ATVBAHA.123.320274. Epub 2024 Feb 8. Arterioscler Thromb Vasc Biol. 2024. PMID: 38328934
177 results