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Effect of Repeated Administration of -Valerolactone (GVL) and GHB in the Mouse: Neuroadaptive Changes of the GHB and GABAergic System.
Frisoni P, Corli G, Bilel S, Tirri M, Gasparini LC, Alfieri L, Neri M, De-Giorgio F, Marti M. Frisoni P, et al. Pharmaceuticals (Basel). 2023 Aug 30;16(9):1225. doi: 10.3390/ph16091225. Pharmaceuticals (Basel). 2023. PMID: 37765033 Free PMC article.
BACKGROUND: Gamma-hydroxybutyric acid (GHB) at low dosages has anxiolytic effects and promotes REM sleep and low-wave deep sleep. In the U.S., the legal form of GHB is prescribed to adults suffering from narcolepsy-associated cataplexy; the sodium salt of GHB is reserved f …
BACKGROUND: Gamma-hydroxybutyric acid (GHB) at low dosages has anxiolytic effects and promotes REM sleep and low-wave deep sleep. In …
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice-from a human poisoning case to the preclinical evidence.
Bassi M, Bilel S, Tirri M, Corli G, Di Rosa F, Gregori A, Alkilany AM, Rachid O, Roda E, Zauli G, Locatelli CA, Marti M. Bassi M, et al. Psychopharmacology (Berl). 2024 Mar;241(3):489-511. doi: 10.1007/s00213-024-06526-8. Epub 2024 Jan 12. Psychopharmacology (Berl). 2024. PMID: 38214743 Free PMC article.
RATIONALE: The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as "Moxy") is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly well-known; however, only few information is ava …
RATIONALE: The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as "Moxy") is a new psychedelic tryptamine first identifie …
Tackling new psychoactive substances through metabolomics: UHPLC-HRMS study on natural and synthetic opioids in male and female murine models.
Di Francesco G, Montesano C, Vincenti F, Bilel S, Corli G, Petrella G, Cicero DO, Gregori A, Marti M, Sergi M. Di Francesco G, et al. Sci Rep. 2024 Apr 24;14(1):9432. doi: 10.1038/s41598-024-60045-2. Sci Rep. 2024. PMID: 38658766 Free PMC article.
Novel psychoactive substances (NPS) represent a broad class of drugs new to the illicit market that often allow passing drug-screening tests. ...The present study aims at developing an indirect screening strategy for NPS monitoring, and s …
Novel psychoactive substances (NPS) represent a broad class of drugs new to the illicit market that often allow passing drug-s …