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Page 1
The NS1 protein: a multitasking virulence factor.
Ayllon J, García-Sastre A. Ayllon J, et al. Curr Top Microbiol Immunol. 2015;386:73-107. doi: 10.1007/82_2014_400. Curr Top Microbiol Immunol. 2015. PMID: 25007846 Review.
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Miller MS, Rialdi A, Ho JS, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre AM, Mitsopoulos P, Madrenas J, Heinz S, Benner C, Young JA, Feagins AR, Basler CF, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I. Miller MS, et al. Nat Immunol. 2015 May;16(5):485-94. doi: 10.1038/ni.3132. Epub 2015 Mar 30. Nat Immunol. 2015. PMID: 25822250 Free PMC article.
Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. Heaton NS, et al. Immunity. 2016 Jan 19;44(1):46-58. doi: 10.1016/j.immuni.2015.12.017. Immunity. 2016. PMID: 26789921 Free PMC article.
Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.
Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. Rialdi A, et al. Science. 2016 May 27;352(6289):aad7993. doi: 10.1126/science.aad7993. Epub 2016 Apr 28. Science. 2016. PMID: 27127234 Free PMC article.
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Rajsbaum R, et al. Immunity. 2014 Jun 19;40(6):880-95. doi: 10.1016/j.immuni.2014.04.018. Epub 2014 May 29. Immunity. 2014. PMID: 24882218 Free PMC article.