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Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, Zhang Z, Arvikar S, Latz E, Fitzgerald KA, Marshall WL. DiPerna G, et al. J Biol Chem. 2004 Aug 27;279(35):36570-8. doi: 10.1074/jbc.M400567200. Epub 2004 Jun 23. J Biol Chem. 2004. PMID: 15215253 Free article.