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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.
Leitsch D, Burgess AG, Dunn LA, Krauer KG, Tan K, Duchêne M, Upcroft P, Eckmann L, Upcroft JA. Leitsch D, et al. J Antimicrob Chemother. 2011 Aug;66(8):1756-65. doi: 10.1093/jac/dkr192. Epub 2011 May 22. J Antimicrob Chemother. 2011. PMID: 21602576 Free PMC article.