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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.
J Antimicrob Chemother. 2011 Aug;66(8):1756-65. doi: 10.1093/jac/dkr192. Epub 2011 May 22.
J Antimicrob Chemother. 2011.
PMID: 21602576
Free PMC article.
A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.
Dunn LA, Burgess AG, Krauer KG, Eckmann L, Vanelle P, Crozet MD, Gillin FD, Upcroft P, Upcroft JA.
Dunn LA, et al.
Int J Antimicrob Agents. 2010 Jul;36(1):37-42. doi: 10.1016/j.ijantimicag.2010.03.004. Epub 2010 Apr 24.
Int J Antimicrob Agents. 2010.
PMID: 20456926
Free PMC article.
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