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Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer's Disease.
Gherardelli C, Cisternas P, Inestrosa NC. Gherardelli C, et al. Int J Mol Sci. 2022 Aug 5;23(15):8733. doi: 10.3390/ijms23158733. Int J Mol Sci. 2022. PMID: 35955868 Free PMC article.
However, despite its widespread use in neuropsychiatric disorders, lithium's effects on the brain have been poorly characterized. Here we evaluated the effect of lithium on glucose metabolism in hippocampal neurons from wild-type (WT) and APPSwe/PS1deltaE9 (A …
However, despite its widespread use in neuropsychiatric disorders, lithium's effects on the brain have been poorly characteriz …
Building a Bridge Between NMDAR-Mediated Excitotoxicity and Mitochondrial Dysfunction in Chronic and Acute Diseases.
Mira RG, Cerpa W. Mira RG, et al. Cell Mol Neurobiol. 2021 Oct;41(7):1413-1430. doi: 10.1007/s10571-020-00924-0. Epub 2020 Jul 22. Cell Mol Neurobiol. 2021. PMID: 32700093 Review.
The calcium entry through extrasynaptic NMDARs is linked to calcium overload in the mitochondria in neurons in vitro. The mitochondria, besides their role in ATP production in the cell, participate in calcium homeostasis, acting as a buffering organelle. ...In this review, …
The calcium entry through extrasynaptic NMDARs is linked to calcium overload in the mitochondria in neurons in vitro. The mitochondria, besi …
Exo70 intracellular redistribution after repeated mild traumatic brain injury.
Lira M, Zamorano P, Cerpa W. Lira M, et al. Biol Res. 2021 Feb 16;54(1):5. doi: 10.1186/s40659-021-00329-3. Biol Res. 2021. PMID: 33593425 Free PMC article.
Although Exo70 function has been implicated in several developmental events including cytokinesis and the establishment of cell polarity, its role in neuropathologies is poorly understood. On the other hand, traumatic brain injury is the result of mechanical external force …
Although Exo70 function has been implicated in several developmental events including cytokinesis and the establishment of cell polarity, it …
Regulation of Phosphorylated State of NMDA Receptor by STEP(61) Phosphatase after Mild-Traumatic Brain Injury: Role of Oxidative Stress.
Carvajal FJ, Cerpa W. Carvajal FJ, et al. Antioxidants (Basel). 2021 Oct 5;10(10):1575. doi: 10.3390/antiox10101575. Antioxidants (Basel). 2021. PMID: 34679709 Free PMC article.
However, the contribution of NMDARs (distribution and signaling-associated to the distribution) remains incompletely understood. We propose a critical role of STEP(61) (Striatal-Enriched protein tyrosine phosphatase) in TBI; this phosphatase regulates the dephosphorylated …
However, the contribution of NMDARs (distribution and signaling-associated to the distribution) remains incompletely understood. We propose …