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2021 1
2022 17
2023 16
2024 0

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31 results

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Page 1
Brain-restricted mTOR inhibition with binary pharmacology.
Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM. Zhang Z, et al. Nature. 2022 Sep;609(7928):822-828. doi: 10.1038/s41586-022-05213-y. Epub 2022 Sep 14. Nature. 2022. PMID: 36104566 Free PMC article.
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. Tolani B, et al. Nat Biotechnol. 2022 Dec;40(12):1834-1844. doi: 10.1038/s41587-022-01386-z. Epub 2022 Jul 25. Nat Biotechnol. 2022. PMID: 35879364 Free PMC article.
IFITM proteins assist cellular uptake of diverse linked chemotypes.
Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. Lou K, et al. Science. 2022 Dec 9;378(6624):1097-1104. doi: 10.1126/science.abl5829. Epub 2022 Dec 8. Science. 2022. PMID: 36480603 Free PMC article.
Signal peptide mimicry primes Sec61 for client-selective inhibition.
Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, Kirk CJ, Huiskonen JT, Taunton J, Paavilainen VO. Rehan S, et al. Nat Chem Biol. 2023 Sep;19(9):1054-1062. doi: 10.1038/s41589-023-01326-1. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169961 Free PMC article.
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
Kenanova DN, Visser EJ, Virta JM, Sijbesma E, Centorrino F, Vickery HR, Zhong M, Neitz RJ, Brunsveld L, Ottmann C, Arkin MR. Kenanova DN, et al. ACS Cent Sci. 2023 Apr 18;9(5):937-946. doi: 10.1021/acscentsci.2c01449. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252362 Free PMC article.
Tissue-restricted inhibition of mTOR using chemical genetics.
Wassarman DR, Bankapalli K, Pallanck LJ, Shokat KM. Wassarman DR, et al. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2204083119. doi: 10.1073/pnas.2204083119. Epub 2022 Sep 12. Proc Natl Acad Sci U S A. 2022. PMID: 36095197 Free PMC article.
31 results