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Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes.
Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H. Chegão A, et al. NPJ Parkinsons Dis. 2022 Apr 25;8(1):51. doi: 10.1038/s41531-022-00314-x. NPJ Parkinsons Dis. 2022. PMID: 35468899 Free PMC article.
Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP. Peixoto DO, et al. J Neurochem. 2023 Sep 3. doi: 10.1111/jnc.15956. Online ahead of print. J Neurochem. 2023. PMID: 37661637