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Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.
Kim HS, Ortiz D, Kadayat TM, Fargo CM, Hammill JT, Chen Y, Rice AL, Begley KL, Shoeran G, Pistel W, Yates PA, Sanchez MA, Landfear SM, Guy RK. Kim HS, et al. J Med Chem. 2023 Jun 8;66(11):7374-7386. doi: 10.1021/acs.jmedchem.3c00056. Epub 2023 May 22. J Med Chem. 2023. PMID: 37216489 Free PMC article.
A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products.
Bhardwaj M, Cui Z, Daniel Hankore E, Moonschi FH, Saghaeiannejad Esfahani H, Kalkreuter E, Gui C, Yang D, Phillips GN Jr, Thorson JS, Shen B, Van Lanen SG. Bhardwaj M, et al. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2220468120. doi: 10.1073/pnas.2220468120. Epub 2023 Feb 21. Proc Natl Acad Sci U S A. 2023. PMID: 36802426 Free PMC article.