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An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor.
Shirai Y, Chow CCT, Kambe G, Suwa T, Kobayashi M, Takahashi I, Harada H, Nam JM. Shirai Y, et al. Cancers (Basel). 2021 Jun 4;13(11):2813. doi: 10.3390/cancers13112813. Cancers (Basel). 2021. PMID: 34200019 Free PMC article. Review.
In order to efficiently inhibit its activity, extensive efforts have been made to elucidate the molecular mechanism underlying the activation of HIF-1. Here, we provide an overview of relevant research, particularly on a series of HIF-1 activators identified so far and the …
In order to efficiently inhibit its activity, extensive efforts have been made to elucidate the molecular mechanism underlying the activatio …