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Filoviral immune evasion mechanisms.
Ramanan P, Shabman RS, Brown CS, Amarasinghe GK, Basler CF, Leung DW. Ramanan P, et al. Viruses. 2011 Sep;3(9):1634-49. doi: 10.3390/v3091634. Epub 2011 Sep 7. Viruses. 2011. PMID: 21994800 Free PMC article. Review.
Aptamers in virology: recent advances and challenges.
Binning JM, Leung DW, Amarasinghe GK. Binning JM, et al. Front Microbiol. 2012 Feb 8;3:29. doi: 10.3389/fmicb.2012.00029. eCollection 2012. Front Microbiol. 2012. PMID: 22347221 Free PMC article.
Ebolavirus VP35 is a multifunctional virulence factor.
Leung DW, Prins KC, Basler CF, Amarasinghe GK. Leung DW, et al. Virulence. 2010 Nov-Dec;1(6):526-31. doi: 10.4161/viru.1.6.12984. Epub 2010 Nov 1. Virulence. 2010. PMID: 21178490 Free PMC article.
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK. Ramanan P, et al. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20661-6. doi: 10.1073/pnas.1213559109. Epub 2012 Nov 26. Proc Natl Acad Sci U S A. 2012. PMID: 23185024 Free PMC article.
In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK. Brown CS, et al. J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1. J Mol Biol. 2014. PMID: 24495995 Free PMC article.