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Year | Number of Results |
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Leukotoxin (LtxA/Leukothera) induces ATP expulsion via pannexin-1 channels and subsequent cell death in malignant lymphocytes.
Sci Rep. 2021 Sep 10;11(1):18086. doi: 10.1038/s41598-021-97545-4.
Sci Rep. 2021.
PMID: 34508147
Free PMC article.
Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes.
Vega BA, Schober LT, Kim T, Belinka BA Jr, Kachlany SC.
Vega BA, et al.
Infect Immun. 2019 Jul 23;87(8):e00309-19. doi: 10.1128/IAI.00309-19. Print 2019 Aug.
Infect Immun. 2019.
PMID: 31109948
Free PMC article.
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Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes.
Kaur M, Kachlany SC.
Kaur M, et al.
Microbiology (Reading). 2014 Nov;160(Pt 11):2443-2452. doi: 10.1099/mic.0.082347-0. Epub 2014 Aug 28.
Microbiology (Reading). 2014.
PMID: 25169107
Free PMC article.
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LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.
DiFranco KM, Johnson-Farley N, Bertino JR, Elson D, Vega BA, Belinka BA Jr, Kachlany SC.
DiFranco KM, et al.
Leuk Res. 2015 Jun;39(6):649-56. doi: 10.1016/j.leukres.2015.03.010. Epub 2015 Mar 21.
Leuk Res. 2015.
PMID: 25850729
Free PMC article.
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