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Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Ronis MJ, Mercer KE, Shankar K, Pulliam C, Pedersen K, Ingelman-Sundberg M, Friso S, Samuelson D, Del Valle L, Taylor C, Welsh DA. Ronis MJ, et al. Chem Biol Interact. 2020 Jul 1;325:109131. doi: 10.1016/j.cbi.2020.109131. Epub 2020 May 14. Chem Biol Interact. 2020. PMID: 32417163 Free PMC article.
Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus.
Pedersen KB, Pulliam CF, Patel A, Del Piero F, Watanabe TTN, Wankhade UD, Shankar K, Hicks C, Ronis MJ. Pedersen KB, et al. Carcinogenesis. 2019 Apr 29;40(2):349-359. doi: 10.1093/carcin/bgy141. Carcinogenesis. 2019. PMID: 30325408 Free PMC article.