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Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core.
Kisiela DI, Magala P, Interlandi G, Carlucci LA, Ramos A, Tchesnokova V, Basanta B, Yarov-Yarovoy V, Avagyan H, Hovhannisyan A, Thomas WE, Stenkamp RE, Klevit RE, Sokurenko EV. Kisiela DI, et al. PLoS Pathog. 2021 Apr 7;17(4):e1009440. doi: 10.1371/journal.ppat.1009440. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33826682 Free PMC article.
Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear.
Thomas WE, Carlucci L, Yakovenko O, Interlandi G, Le Trong I, Aprikian P, Magala P, Larson L, Sledneva Y, Tchesnokova V, Stenkamp RE, Sokurenko EV. Thomas WE, et al. J Mol Biol. 2022 Sep 15;434(17):167681. doi: 10.1016/j.jmb.2022.167681. Epub 2022 Jun 11. J Mol Biol. 2022. PMID: 35697293 Free PMC article.