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Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog.
J Biol Chem. 2023 Sep;299(9):105148. doi: 10.1016/j.jbc.2023.105148. Epub 2023 Aug 9.
J Biol Chem. 2023.
PMID: 37567474
Free PMC article.
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Oellerich T, Schneider C, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT, Cinatl J Jr.
Oellerich T, et al.
Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4.
Nat Commun. 2019.
PMID: 31375673
Free PMC article.
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The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Qin Z, Bonifati S, St Gelais C, Li TW, Kim SH, Antonucci JM, Mahboubi B, Yount JS, Xiong Y, Kim B, Wu L.
Qin Z, et al.
J Biol Chem. 2020 Feb 7;295(6):1575-1586. doi: 10.1074/jbc.RA119.010360. Epub 2019 Dec 30.
J Biol Chem. 2020.
PMID: 31914403
Free PMC article.
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The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J Jr, Keppler OT, Xiong Y.
Knecht KM, et al.
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10022-E10031. doi: 10.1073/pnas.1805593115. Epub 2018 Oct 10.
Proc Natl Acad Sci U S A. 2018.
PMID: 30305425
Free PMC article.
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Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Bowen NE, Temple J, Shepard C, Oo A, Arizaga F, Kapoor-Vazirani P, Persaud M, Yu CH, Kim DH, Schinazi RF, Ivanov DN, Diaz-Griffero F, Yu DS, Xiong Y, Kim B.
Bowen NE, et al.
J Biol Chem. 2021 Oct;297(4):101170. doi: 10.1016/j.jbc.2021.101170. Epub 2021 Sep 4.
J Biol Chem. 2021.
PMID: 34492268
Free PMC article.
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