R15 HL093708/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2012	2
2013	1
2014	1
2015	1
2016	1
2019	1
2020	3
2021	2
2024	0

1

The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases.

Wang M, Gauthier A, Daley L, Dial K, Wu J, Woo J, Lin M, Ashby C, Mantell LL. Wang M, et al. Antioxid Redox Signal. 2019 Nov 1;31(13):954-993. doi: 10.1089/ars.2019.7818. Epub 2019 Jul 11. Antioxid Redox Signal. 2019. PMID: 31184204 Free PMC article. Review.

2

Ascorbic Acid Attenuates Hyperoxia-Compromised Host Defense against Pulmonary Bacterial Infection.

Patel VS, Sampat V, Espey MG, Sitapara R, Wang H, Yang X, Ashby CR Jr, Thomas DD, Mantell LL. Patel VS, et al. Am J Respir Cell Mol Biol. 2016 Oct;55(4):511-520. doi: 10.1165/rcmb.2015-0310OC. Am J Respir Cell Mol Biol. 2016. PMID: 27120084 Free PMC article.

3

From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19?

Gauthier AG, Lin M, Wu J, Kennedy TP, Daley LA, Ashby CR Jr, Mantell LL. Gauthier AG, et al. J Immunotoxicol. 2021 Dec;18(1):23-29. doi: 10.1080/1547691X.2021.1875085. J Immunotoxicol. 2021. PMID: 33860730

4

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function.

Wang M, Gauthier AG, Kennedy TP, Wang H, Velagapudi UK, Talele TT, Lin M, Wu J, Daley L, Yang X, Patel V, Mun SS, Ashby CR Jr, Mantell LL. Wang M, et al. Mol Med. 2021 Jul 16;27(1):79. doi: 10.1186/s10020-021-00334-y. Mol Med. 2021. PMID: 34271850 Free PMC article.

5

The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function.

Sitapara RA, Gauthier AG, Patel VS, Lin M, Zur M, Ashby CR Jr, Mantell LL. Sitapara RA, et al. Mol Med. 2020 Oct 30;26(1):98. doi: 10.1186/s10020-020-00224-9. Mol Med. 2020. PMID: 33126860 Free PMC article.

6

The nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate/D-NO), increases survival by attenuating hyperoxia-compromised innate immunity in bacterial clearance in a mouse model of ventilator-associated pneumonia.

Gore A, Gauthier AG, Lin M, Patel V, Thomas DD, Ashby CR Jr, Mantell LL. Gore A, et al. Biochem Pharmacol. 2020 Jun;176:113817. doi: 10.1016/j.bcp.2020.113817. Epub 2020 Jan 20. Biochem Pharmacol. 2020. PMID: 31972169 Free PMC article.

7

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury.

Entezari M, Javdan M, Antoine DJ, Morrow DM, Sitapara RA, Patel V, Wang M, Sharma L, Gorasiya S, Zur M, Wu W, Li J, Yang H, Ashby CR, Thomas D, Wang H, Mantell LL. Entezari M, et al. Redox Biol. 2014 Jan 20;2:314-22. doi: 10.1016/j.redox.2014.01.013. eCollection 2014. Redox Biol. 2014. PMID: 24563849 Free PMC article.

8

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.

Sitapara RA, Gauthier AG, Valdés-Ferrer SI, Lin M, Patel V, Wang M, Martino AT, Perron JC, Ashby CR Jr, Tracey KJ, Pavlov VA, Mantell LL. Sitapara RA, et al. Mol Med. 2020 Jun 29;26(1):63. doi: 10.1186/s10020-020-00177-z. Mol Med. 2020. PMID: 32600307 Free PMC article.

9

The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1.

Wang M, Gorasiya S, Antoine DJ, Sitapara RA, Wu W, Sharma L, Yang H, Ashby CR Jr, Vasudevan D, Zur M, Thomas DD, Mantell LL. Wang M, et al. Am J Respir Cell Mol Biol. 2015 Feb;52(2):171-82. doi: 10.1165/rcmb.2013-0544OC. Am J Respir Cell Mol Biol. 2015. PMID: 24992505 Free PMC article.

10

Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis.

Entezari M, Weiss DJ, Sitapara R, Whittaker L, Wargo MJ, Li J, Wang H, Yang H, Sharma L, Phan BD, Javdan M, Chavan SS, Miller EJ, Tracey KJ, Mantell LL. Entezari M, et al. Mol Med. 2012 May 9;18(1):477-85. doi: 10.2119/molmed.2012.00024. Mol Med. 2012. PMID: 22314397 Free PMC article.

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