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Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway.
Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):682-91. doi: 10.1016/j.bbadis.2010.05.006. Epub 2010 May 20.
Biochim Biophys Acta. 2010.
PMID: 20493254
Free PMC article.
Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts.
Kosicek M, Malnar M, Goate A, Hecimovic S.
Kosicek M, et al.
Biochem Biophys Res Commun. 2010 Mar 12;393(3):404-9. doi: 10.1016/j.bbrc.2010.02.007. Epub 2010 Feb 6.
Biochem Biophys Res Commun. 2010.
PMID: 20138836
Free PMC article.
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