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Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge.
Malhi H, Homad LJ, Wan YH, Poudel B, Fiala B, Borst AJ, Wang JY, Walkey C, Price J, Wall A, Singh S, Moodie Z, Carter L, Handa S, Correnti CE, Stoddard BL, Veesler D, Pancera M, Olson J, King NP, McGuire AT. Malhi H, et al. Cell Rep Med. 2022 Jun 21;3(6):100658. doi: 10.1016/j.xcrm.2022.100658. Epub 2022 Jun 14. Cell Rep Med. 2022. PMID: 35705092 Free PMC article.
Stepwise design of pseudosymmetric protein hetero-oligomers.
Kibler RD, Lee S, Kennedy MA, Wicky BIM, Lai SM, Kostelic MM, Li X, Chow CM, Carter L, Wysocki VH, Stoddard BL, Baker D. Kibler RD, et al. bioRxiv [Preprint]. 2023 Apr 7:2023.04.07.535760. doi: 10.1101/2023.04.07.535760. bioRxiv. 2023. PMID: 37066191 Free PMC article. Preprint.
De novo design of knotted tandem repeat proteins.
Doyle LA, Takushi B, Kibler RD, Milles LF, Orozco CT, Jones JD, Jackson SE, Stoddard BL, Bradley P. Doyle LA, et al. Nat Commun. 2023 Oct 24;14(1):6746. doi: 10.1038/s41467-023-42388-y. Nat Commun. 2023. PMID: 37875492 Free PMC article.
De novo design of protein homodimers containing tunable symmetric protein pockets.
Hicks DR, Kennedy MA, Thompson KA, DeWitt M, Coventry B, Kang A, Bera AK, Brunette TJ, Sankaran B, Stoddard B, Baker D. Hicks DR, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2113400119. doi: 10.1073/pnas.2113400119. Epub 2022 Jul 21. Proc Natl Acad Sci U S A. 2022. PMID: 35862457 Free PMC article.
De novo design of energy transfer proteins housing excitonically coupled chlorophyll special pairs.
Ennist N, Wang S, Kennedy M, Curti M, Sutherland G, Vasilev C, Redler R, Maffeis V, Shareef S, Sica A, Hua A, Deshmukh A, Moyer A, Hicks D, Swartz A, Cacho R, Novy N, Bera A, Kang A, Sankaran B, Johnson M, Reppert M, Ekiert D, Bhabha G, Stewart L, Caram J, Stoddard B, Romero E, Hunter CN, Baker D. Ennist N, et al. Res Sq [Preprint]. 2023 Apr 21:rs.3.rs-2736786. doi: 10.21203/rs.3.rs-2736786/v1. Res Sq. 2023. PMID: 37131790 Free PMC article. Preprint.