R01 GM104212/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2013	1
2014	2
2015	9
2016	5
2017	12
2018	2
2020	1
2024	0

1

Androgen receptor: structure, role in prostate cancer and drug discovery.

Tan MH, Li J, Xu HE, Melcher K, Yong EL. Tan MH, et al. Acta Pharmacol Sin. 2015 Jan;36(1):3-23. doi: 10.1038/aps.2014.18. Epub 2014 Jun 9. Acta Pharmacol Sin. 2015. PMID: 24909511 Free PMC article. Review.

2

A structural snapshot of the rhodopsin-arrestin complex.

Kang Y, Gao X, Zhou XE, He Y, Melcher K, Xu HE. Kang Y, et al. FEBS J. 2016 Mar;283(5):816-21. doi: 10.1111/febs.13561. Epub 2015 Nov 7. FEBS J. 2016. PMID: 26467309 Free PMC article. Review.

3

γ-Secretase Epsilon-cleavage Assay.

Xu TH, Yan Y, Harikumar KG, Miller LJ, Melcher K, Xu HE. Xu TH, et al. Bio Protoc. 2017 Nov 20;7(22):e2900. doi: 10.21769/BioProtoc.2900. Bio Protoc. 2017. PMID: 29392164 Free PMC article.

4

Structural basis of AMPK regulation by adenine nucleotides and glycogen.

Li X, Wang L, Zhou XE, Ke J, de Waal PW, Gu X, Tan MH, Wang D, Wu D, Xu HE, Melcher K. Li X, et al. Cell Res. 2015 Jan;25(1):50-66. doi: 10.1038/cr.2014.150. Epub 2014 Nov 21. Cell Res. 2015. PMID: 25412657 Free PMC article.

5

Defining the minimum substrate and charge recognition model of gamma-secretase.

Yan Y, Xu TH, Melcher K, Xu HE. Yan Y, et al. Acta Pharmacol Sin. 2017 Oct;38(10):1412-1424. doi: 10.1038/aps.2017.35. Epub 2017 Apr 17. Acta Pharmacol Sin. 2017. PMID: 28414207 Free PMC article.

6

Streptavidin Bead Pulldown Assay to Determine Protein Homooligomerization.

Xu TH, Yan Y, Harikumar KG, Miller LJ, Melcher K, Xu HE. Xu TH, et al. Bio Protoc. 2017 Nov 20;7(22):e2901. doi: 10.21769/BioProtoc.2901. Bio Protoc. 2017. PMID: 29392166 Free PMC article.

7

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing.

Gu X, Yan Y, Novick SJ, Kovach A, Goswami D, Ke J, Tan MHE, Wang L, Li X, de Waal PW, Webb MR, Griffin PR, Xu HE, Melcher K. Gu X, et al. J Biol Chem. 2017 Jul 28;292(30):12653-12666. doi: 10.1074/jbc.M117.793018. Epub 2017 Jun 14. J Biol Chem. 2017. PMID: 28615457 Free PMC article.

8

Structural basis for molecular recognition of folic acid by folate receptors.

Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K. Chen C, et al. Nature. 2013 Aug 22;500(7463):486-9. doi: 10.1038/nature12327. Epub 2013 Jul 14. Nature. 2013. PMID: 23851396 Free PMC article.

9

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.

10

Structural basis of the Norrin-Frizzled 4 interaction.

Shen G, Ke J, Wang Z, Cheng Z, Gu X, Wei Y, Melcher K, Xu HE, Xu W. Shen G, et al. Cell Res. 2015 Sep;25(9):1078-81. doi: 10.1038/cr.2015.92. Epub 2015 Jul 31. Cell Res. 2015. PMID: 26227961 Free PMC article. No abstract available.

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