R01 DK052962/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2001	1
2002	1
2005	3
2006	1
2009	1
2010	1
2011	2
2012	1
2013	2
2014	3
2015	2
2016	3
2017	2
2018	1
2021	1
2024	0

1

Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies.

Perrine SP, Pace BS, Faller DV. Perrine SP, et al. Hematol Oncol Clin North Am. 2014 Apr;28(2):233-48. doi: 10.1016/j.hoc.2013.11.009. Hematol Oncol Clin North Am. 2014. PMID: 24589264 Review.

2

An oral Hemokine^TM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.

Faller DV, Castaneda SA, Zhou D, Vedamony M, Newburger PE, White GL, Kosanke S, Plett PA, Orschell CM, Boosalis MS, Perrine SP. Faller DV, et al. Blood Cells Mol Dis. 2017 Mar;63:1-8. doi: 10.1016/j.bcmd.2016.10.021. Epub 2016 Oct 31. Blood Cells Mol Dis. 2017. PMID: 27888688 Free PMC article.

3

Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.

Dai Y, Sangerman J, Luo HY, Fucharoen S, Chui DH, Faller DV, Perrine SP. Dai Y, et al. Blood Cells Mol Dis. 2016 Jan;56(1):62-9. doi: 10.1016/j.bcmd.2015.10.004. Epub 2015 Oct 27. Blood Cells Mol Dis. 2016. PMID: 26603726 Free PMC article.

4

Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.

Pace BS, Perrine S, Li B, Makala L, Xu H, Takezaki M, Wolf RF, Wang A, Xu X, Huang J, Alimardanov A, Tawa GJ, Sangerman J, Faller A, Zheng W, Toney L, Haugabook SJ. Pace BS, et al. Blood Cells Mol Dis. 2021 Jul;89:102561. doi: 10.1016/j.bcmd.2021.102561. Epub 2021 Mar 12. Blood Cells Mol Dis. 2021. PMID: 33744514 Free PMC article.

5

A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.

Fucharoen S, Inati A, Siritanaratku N, Thein SL, Wargin WC, Koussa S, Taher A, Chaneim N, Boosalis M, Berenson R, Perrine SP. Fucharoen S, et al. Br J Haematol. 2013 May;161(4):587-93. doi: 10.1111/bjh.12304. Epub 2013 Mar 27. Br J Haematol. 2013. PMID: 23530969 Free PMC article. Clinical Trial.

6

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation.

Boosalis MS, Bandyopadhyay R, Bresnick EH, Pace BS, Van DeMark K, Zhang B, Faller DV, Perrine SP. Boosalis MS, et al. Blood. 2001 May 15;97(10):3259-67. doi: 10.1182/blood.v97.10.3259. Blood. 2001. PMID: 11342457 Free PMC article.

7

Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.

Boosalis MS, Castaneda SA, Trudel M, Mabaera R, White GL, Lowrey CH, Emery DW, Mpollo MS, Shen L, Wargin WA, Bohacek R, Faller DV, Perrine SP. Boosalis MS, et al. Blood Cells Mol Dis. 2011 Aug 15;47(2):107-16. doi: 10.1016/j.bcmd.2011.04.008. Blood Cells Mol Dis. 2011. PMID: 21641240 Free PMC article.

8

Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer.

Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S. Dai Y, et al. Am J Hematol. 2017 Jan;92(1):E10-E11. doi: 10.1002/ajh.24590. Epub 2016 Nov 18. Am J Hematol. 2017. PMID: 27766663 Free PMC article. No abstract available.

9

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia.

Patthamalai P, Fuchareon S, Chaneiam N, Ghalie RG, Chui DH, Boosalis MS, Perrine SP. Patthamalai P, et al. Blood. 2014 Mar 20;123(12):1956-7. doi: 10.1182/blood-2013-11-538470. Blood. 2014. PMID: 24652964 Free PMC article. Clinical Trial. No abstract available.

10

Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.

Perrine SP, Wargin WA, Boosalis MS, Wallis WJ, Case S, Keefer JR, Faller DV, Welch WC, Berenson RJ. Perrine SP, et al. J Clin Pharmacol. 2011 Aug;51(8):1186-94. doi: 10.1177/0091270010379810. Epub 2011 Mar 21. J Clin Pharmacol. 2011. PMID: 21422239 Free PMC article. Clinical Trial.

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