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The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining.
Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcalá K, Ball K, Proctor B 3rd, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N. Fleury H, et al. Mol Cell. 2023 May 4;83(9):1429-1445.e8. doi: 10.1016/j.molcel.2023.03.017. Epub 2023 Apr 11. Mol Cell. 2023. PMID: 37044098 Free PMC article.
Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models.
Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, Jeong AD, Guntupalli SR, Behbakht K, Gbaja V, Arnoult N, Chuong EB, Bitler BG. Nguyen LL, et al. bioRxiv [Preprint]. 2023 Feb 23:2023.02.23.529773. doi: 10.1101/2023.02.23.529773. bioRxiv. 2023. PMID: 36865165 Free PMC article. Preprint.