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Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance.
J Clin Invest. 2023 Nov 1;133(21):e167951. doi: 10.1172/JCI167951.
J Clin Invest. 2023.
PMID: 37651197
Free PMC article.
Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer.
Eisa NH, Crowley VM, Elahi A, Kommalapati VK, Serwetnyk MA, Llbiyi T, Lu S, Kainth K, Jilani Y, Marasco D, El Andaloussi A, Lee S, Tsai FTF, Rodriguez PC, Munn D, Celis E, Korkaya H, Debbab A, Blagg B, Chadli A.
Eisa NH, et al.
iScience. 2023 Oct 24;26(12):108308. doi: 10.1016/j.isci.2023.108308. eCollection 2023 Dec 15.
iScience. 2023.
PMID: 38025772
Free PMC article.
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Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin).
Patwardhan CA, Kommalapati VK, Llbiyi T, Singh D, Alfa E, Horuzsko A, Korkaya H, Panda S, Reilly CA, Popik V, Chadli A.
Patwardhan CA, et al.
Sci Rep. 2023 Aug 23;13(1):13790. doi: 10.1038/s41598-023-40933-9.
Sci Rep. 2023.
PMID: 37612326
Free PMC article.
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Enniatin A Analogues as Novel Hsp90 Inhibitors that Modulate Triple-Negative Breast Cancer.
Serwetnyk MA, Crowley VM, Brackett CM, Carter TR, Elahi A, Kommalapati VK, Chadli A, Blagg BSJ.
Serwetnyk MA, et al.
ACS Med Chem Lett. 2023 Nov 17;14(12):1785-1790. doi: 10.1021/acsmedchemlett.3c00423. eCollection 2023 Dec 14.
ACS Med Chem Lett. 2023.
PMID: 38116437
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