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Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden.
Zhu M, Kim J, Deng Q, Ricciuti B, Alessi JV, Eglenen-Polat B, Bender ME, Huang HC, Kowash RR, Cuevas I, Bennett ZT, Gao J, Minna JD, Castrillon DH, Awad MM, Xu L, Akbay EA. Zhu M, et al. Cancer Cell. 2023 Oct 9;41(10):1731-1748.e8. doi: 10.1016/j.ccell.2023.09.006. Epub 2023 Sep 28. Cancer Cell. 2023. PMID: 37774698
Endometrial polyps are non-neoplastic but harbor epithelial mutations in endometrial cancer drivers at low allelic frequencies.
Sahoo SS, Aguilar M, Xu Y, Lucas E, Miller V, Chen H, Zheng W, Cuevas IC, Li HD, Hitrys D, Wachsmann MB, Bishop JA, Cantarell B, Gagan J, Koduru P, SoRelle JA, Castrillon DH. Sahoo SS, et al. Mod Pathol. 2022 Nov;35(11):1702-1712. doi: 10.1038/s41379-022-01124-5. Epub 2022 Jul 7. Mod Pathol. 2022. PMID: 35798968 Free PMC article.