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CD1a function in human skin disease.
de Jong A, Ogg G. de Jong A, et al. Mol Immunol. 2021 Feb;130:14-19. doi: 10.1016/j.molimm.2020.12.006. Epub 2020 Dec 18. Mol Immunol. 2021. PMID: 33348245 Free PMC article. Review.
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Monnot GC, Wegrecki M, Cheng TY, Chen YL, Sallee BN, Chakravarthy R, Karantza IM, Tin SY, Khaleel AE, Monga I, Uwakwe LN, Tillman A, Cheng B, Youssef S, Ng SW, Shahine A, Garcia-Vilas JA, Uhlemann AC, Bordone LA, Han A, Rohde CH, Ogg G, Moody DB, Rossjohn J, de Jong A. Monnot GC, et al. Nat Immunol. 2023 Jan;24(1):110-122. doi: 10.1038/s41590-022-01375-z. Epub 2022 Dec 22. Nat Immunol. 2023. PMID: 36550321 Free PMC article.
Human skin is colonized by T cells that recognize CD1a independently of lipid.
Cotton RN, Cheng TY, Wegrecki M, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis RA, Altman JD, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark RA, Moody DB. Cotton RN, et al. J Clin Invest. 2021 Jan 4;131(1):e140706. doi: 10.1172/JCI140706. J Clin Invest. 2021. PMID: 33393500 Free PMC article.
CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
Cotton RN, Wegrecki M, Cheng TY, Chen YL, Veerapen N, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis R, Altman JD, de Jong A, Van Rhijn I, Clark RA, Besra GS, Ogg G, Rossjohn J, Moody DB. Cotton RN, et al. J Exp Med. 2021 Jul 5;218(7):e20202699. doi: 10.1084/jem.20202699. Epub 2021 May 7. J Exp Med. 2021. PMID: 33961028 Free PMC article.