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HSP70i is a critical component of the immune response leading to vitiligo.
Mosenson JA, Zloza A, Klarquist J, Barfuss AJ, Guevara-Patino JA, Poole IC. Mosenson JA, et al. Pigment Cell Melanoma Res. 2012 Jan;25(1):88-98. doi: 10.1111/j.1755-148X.2011.00916.x. Epub 2011 Nov 14. Pigment Cell Melanoma Res. 2012. PMID: 21978301 Free PMC article.
HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
Denman CJ, McCracken J, Hariharan V, Klarquist J, Oyarbide-Valencia K, Guevara-Patiño JA, Le Poole IC. Denman CJ, et al. J Invest Dermatol. 2008 Aug;128(8):2041-8. doi: 10.1038/jid.2008.45. Epub 2008 Mar 13. J Invest Dermatol. 2008. PMID: 18337834 Free PMC article.
Mutant HSP70 reverses autoimmune depigmentation in vitiligo.
Mosenson JA, Zloza A, Nieland JD, Garrett-Mayer E, Eby JM, Huelsmann EJ, Kumar P, Denman CJ, Lacek AT, Kohlhapp FJ, Alamiri A, Hughes T, Bines SD, Kaufman HL, Overbeck A, Mehrotra S, Hernandez C, Nishimura MI, Guevara-Patino JA, Le Poole IC. Mosenson JA, et al. Sci Transl Med. 2013 Feb 27;5(174):174ra28. doi: 10.1126/scitranslmed.3005127. Sci Transl Med. 2013. PMID: 23447019 Free PMC article.