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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2.
Barnett KC, Xie Y, Asakura T, Song D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin Iii TH, Sempowski GD, Randell SH, Heise MT, Lei YL, Boucher RC, Ting JP. Barnett KC, et al. Cell Host Microbe. 2023 Feb 8;31(2):243-259.e6. doi: 10.1016/j.chom.2022.12.005. Epub 2022 Dec 9. Cell Host Microbe. 2023. PMID: 36563691 Free PMC article.
Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements.
Snouwaert JN, Jania LA, Nguyen T, Martinez DR, Schäfer A, Catanzaro NJ, Gully KL, Baric RS, Heise M, Ferris MT, Anderson E, Pressey K, Dillard JA, Taft-Benz S, Baxter VK, Ting JP, Koller BH. Snouwaert JN, et al. PLoS Pathog. 2023 Feb 22;19(2):e1011168. doi: 10.1371/journal.ppat.1011168. eCollection 2023 Feb. PLoS Pathog. 2023. PMID: 36812267 Free PMC article.