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Selective Bcl-2 inhibition promotes hematopoietic chimerism and allograft tolerance without myelosuppression in nonhuman primates.
Sasaki H, Hirose T, Oura T, Otsuka R, Rosales I, Ma D, Lassiter G, Karadagi A, Tomosugi T, Dehnadi A, Matsunami M, Raju Paul S, Reeves PM, Hanekamp I, Schwartz S, Colvin RB, Lee H, Spitzer TR, Cosimi AB, Cippà PE, Fehr T, Kawai T. Sasaki H, et al. Sci Transl Med. 2023 Apr 5;15(690):eadd5318. doi: 10.1126/scitranslmed.add5318. Epub 2023 Apr 5. Sci Transl Med. 2023. PMID: 37018417 Free PMC article.
TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival.
Lassiter G, Otsuka R, Hirose T, Rosales I, Karadagi A, Tomosugi T, Dehnadi A, Lee H, Colvin RB, Baardsnes J, Moraitis A, Smith EE, Ali Z, Berhe P, Mulder A, Meibohm B, Daugherty B, Fogarty S, Pierson RN, Lederman S, Kawai T. Lassiter G, et al. Am J Transplant. 2023 Aug;23(8):1171-1181. doi: 10.1016/j.ajt.2023.03.022. Epub 2023 Apr 4. Am J Transplant. 2023. PMID: 37019335 Free article.