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Cryo-EM structure of the DNA-PK holoenzyme.
Sharif H, Li Y, Dong Y, Dong L, Wang WL, Mao Y, Wu H. Sharif H, et al. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7367-7372. doi: 10.1073/pnas.1707386114. Epub 2017 Jun 26. Proc Natl Acad Sci U S A. 2017. PMID: 28652322 Free PMC article.
Gasdermin D activity in inflammation and host defense.
Lieberman J, Wu H, Kagan JC. Lieberman J, et al. Sci Immunol. 2019 Sep 6;4(39):eaav1447. doi: 10.1126/sciimmunol.aav1447. Sci Immunol. 2019. PMID: 31492708 Free PMC article. Review.
DNA melting initiates the RAG catalytic pathway.
Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H. Ru H, et al. Nat Struct Mol Biol. 2018 Aug;25(8):732-742. doi: 10.1038/s41594-018-0098-5. Epub 2018 Jul 30. Nat Struct Mol Biol. 2018. PMID: 30061602 Free PMC article.
Characterization of T and B cell repertoire diversity in patients with RAG deficiency.
Lee YN, Frugoni F, Dobbs K, Tirosh I, Du L, Ververs FA, Ru H, Ott de Bruin L, Adeli M, Bleesing JH, Buchbinder D, Butte MJ, Cancrini C, Chen K, Choo S, Elfeky RA, Finocchi A, Fuleihan RL, Gennery AR, El-Ghoneimy DH, Henderson LA, Al-Herz W, Hossny E, Nelson RP, Pai SY, Patel NC, Reda SM, Soler-Palacin P, Somech R, Palma P, Wu H, Giliani S, Walter JE, Notarangelo LD. Lee YN, et al. Sci Immunol. 2016 Dec 16;1(6):eaah6109. doi: 10.1126/sciimmunol.aah6109. Epub 2016 Dec 16. Sci Immunol. 2016. PMID: 28783691 Free PMC article.